https://arvinfomedia.com/myjournals/index.php/RHRIFN <p><strong>Research Horizons: Research and Innovation in Food Nutrition</strong> is a peer-reviewed journal committed to publishing high-quality original research, systematic reviews, and selected high-impact reprints in the scientific, technological, and policy aspects of nutrition and food systems. The journal emphasizes the composition, bioactivity, functionality, and health impacts of foods and their constituents, covering studies on nutrient absorption, bioavailability, personalized nutrition, and gut microbiota interactions.</p> <p>Published half-yearly, the journal is available in both print and electronic formats, ensuring wide accessibility to the research community.​</p> en-US Research Horizons: Research & Innovation in Food Nutrition https://arvinfomedia.com/myjournals/index.php/RHRIFN/article/view/455 <p>Background: Acute Graft versus Host Disease (aGvHD) is a serious complication of allogeneic stem cell transplantation (Allo-SCT) associated with substantial morbidity and mortality. Enteral nutrition (EN) has been associated with improved transplant outcomes, yet standardized early EN practices remain inconsistently adopted across centers. Methods: This retrospective cohort study evaluated the adoption and clinical outcomes of a standardized Day +1 EN protocol in patients undergoing Allo-SCT. The protocol included feeding tube (FT) placement on Day +1 with EN initiated at 25 mL/h. Demographic and clinical data were extracted from electronic health records for patients treated after protocol adoption (post-protocol) and retrospective controls from one year prior (pre-protocol group). Outcomes included successful Day +1 EN initiation, gastrointestinal (GI) complications,<br>FT removal reason, and occurrence and severity of lower GI and overall aGvHD by Day +100 (Modified Glucksberg Criteria). Group comparisons used Welch’s t-test and Fisher’s Exact test (p &lt; 0.05). Results: The final cohort included 108 patients (67 pre-protocol and 41 post-protocol). Successful Day +1 EN initiation occurred in 95.1% (n = 39) of patients post-protocol versus 4.5% (n = 3) pre-protocol (p &lt; 0.001). GI complications and FT removal reason did not differ significantly between groups, and no FTs were removed due to adverse events. The occurrence of lower GI aGvHD was significantly lower post-protocol (12.2% vs. 28.4%, p = 0.05). Conclusions: Adoption of a standardized Day +1 EN protocol in Allo-SCT patients was successfully implemented and well-tolerated without adverse FT-related events. The significant difference in lower GI GvHD occurrence in the post-protocol group warrants confirmation of Day+1 EN in patients receiving an Allo-SCT in a future randomized trial.</p> Nikki Spurgeon Jana Ponce Peyton Hainline Michael Haddadin Vijaya Raj Bhatt Christopher Wichman Emily Thompson Md Saif Uddin Rashed Jacque Schwartz Corri Hanson Mariah Jackson Copyright (c) 2026 Research Horizons: Research & Innovation in Food Nutrition 2026-09-23 2026-09-23 1–12 1–12